THE DEFINITIVE GUIDE TO LSD CRYSTAL

Within the LSD-sure crystal structure, the side chain in the lid residue L209EL2 kinds comprehensive hydrophobic contacts with both of those LSD and bordering residues in TMs III, IV, and V (Determine 4C). Once the lid moved apart to reveal the binding pocket in simulation, many of such contacts broke. We thus hypothesized that L209EL2 functions as